Strange twists in a DNA message

JCVI

This strain of Mycoplasma bacteria contains a genetically encoded quotation from physicist Richard Feynman ... which is wrong.

The pioneer who produced the first organism programmed with synthetic DNA admits that the creature's genetically coded message really needs to be corrected.

Last year, geneticist J. Craig Venter and his colleagues announced that they basically hijacked the genetic machinery of a strain of bacteria known as Mycoplasma capricolum, by implanting the synthetically produced DNA patterned after a different strain, M. mycoides. The researchers added a few coded "watermarks" to the DNA, to prove that the resulting organism really did reflect the synthetic genome.

The watermarks consist of triplets of DNA pairs, with each triplet representing a character of text. For example, a string of guanine, thymine and cytosine, or GTC, stands for the letter "T." The DNA string was built up to spell the names of Venter and his collaborators, as well as a snippet of HTML Web coding and three well-known quotations.

  • "To live, to err, to fall, to triumph, to recreate life out of life." — James Joyce (in "A Portrait of the Artist as a Young Man")
  • "See things not as they are, but as they might be." — Manhattan Project physicist J. Robert Oppenheimer (as quoted in "American Prometheus")
  • "What I cannot build, I cannot understand," — Quantum physicist Richard Feynman

The only problem is, that Feynman quote is wrong. The classic Feynman quote, as written on a blackboard at Caltech just before he died, goes like this: "What I cannot create, I do not understand."

Plenty of Feynman fans pointed out the misquote soon after the Mycoplasma research was announced last May, but the error seemed destined to go down as one of history's enduring quotroversies, alongside Neil Armstrong's long-debated "One Small Step" declaration from the lunar surface. Until now.

As David Ewalt reported on Forbes' Metagamer blog, Venter fessed up to the error during this month's South by Southwest conference in Austin, Texas. The geneticist said that Caltech sent him a note about the misquote, and even included a picture of the blackboard displaying the correct version.

"We agreed what was on the Internet was wrong," Ewalt quoted Venter as saying. "So we're going back to change the genetic code to correct it."

Does that mean the Venter team's synthetic bacterium will be re-engineered? Heather Kowalski, a spokeswoman for the J. Craig Venter Institute (and Venter's wife), couldn't immediately confirm that part of the story. But she did clarify another angle, having to do with that James Joyce quote.

Joyce's estate is notoriously vigilant in its efforts to guard against unauthorized use of the Irish author's prose — and in his report from SXSW, Ewalt quoted Venter as saying that the research team received a "cease and desist" letter from the estate, complaining that the "Life Out of Life" sentence had been used without permission.

In her email, Kowalski told me that the reports about the letter had "gotten a little out of whack," and that there was no legal action in the works.

"The Joyce Estate legal team sent a letter expressing 'disappointment' that JCVI/Craig did not seek permissions from the Estate to use the quote that was encoded into the first synthetic cell," she wrote. "Our lawyers believed and continue to believe that there was indeed fair use of the quote, and there has not been any further correspondence on either part since that initial letter from the Estate."

If Venter really does tweak the synthetic DNA to fix the Feynman quote, I'd love to see him add yet another quotation to reflect on these latest twists. Here's my suggestion, from "Ulysses," James Joyce's masterwork: "A man of genius makes no mistakes. His errors are volitional and are the portals of discovery."

What quote would you enshrine in a bacterium? Feel free to add your favorites in the comment space below.

Update for 3 a.m. ET March 29: Here's what Kowalski had to say about the Feynman quote in a follow-up email: "Craig says it will be corrected in the synthetic cell."

More about synthetic genomics:


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All matter is merely energy condensed to a slow vibration, we are all one consciousness experiencing itself subjectively. there’s no such thing as death, life is only a dream, and we are the imagination of ourselves.

Bill Hicks

    Reply#31 - Tue Mar 29, 2011 9:16 AM EDT

    "… We live in a world where John Lennon was murdered, yet Barry Manilow continues to put out f***ing albums. G**-dammit! If you're gonna kill somebody, have some f***ing taste. I'll drive you to Kenny Rogers' house." - Bill Hicks

    • 1 vote
    #31.1 - Tue Mar 29, 2011 1:29 PM EDT
    Reply

    Any sufficiently advanced technology is indistinguishable from magic. Arthur C. Clarke

    • 4 votes
    Reply#32 - Tue Mar 29, 2011 9:25 AM EDT

    And we have the WINNER! That is the BEST quote to encode!

    • 2 votes
    #32.1 - Tue Mar 29, 2011 9:39 AM EDT

    When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is very probably wrong. -Clarke's first law

    • 3 votes
    #32.2 - Tue Mar 29, 2011 1:33 PM EDT

    We all seem to have a Clarke quote:

    "Every revolutionary idea seems to evoke three stages of reaction. They may be summed up by the phrases: One, it's completely impossible. Two, it's possible, but it's not worth doing. Three, I said it was a good idea all along." – Arthur C. Clarke

    • 2 votes
    #32.3 - Tue Mar 29, 2011 2:23 PM EDT

    One of my favorites from the man is

    "I can never look now at the Milky Way without wondering from which of those banked clouds of stars the emissaries are coming. If you will pardon so commonplace a simile, we have set off the fire alarm and have nothing to do but to wait.

    I do not think we will have to wait for long"

      #32.4 - Tue Mar 29, 2011 2:48 PM EDT
      Reply

      oops, I did it again

      • 1 vote
      Reply#33 - Tue Mar 29, 2011 9:48 AM EDT

      I think ...therefore I am

      • 1 vote
      Reply#34 - Tue Mar 29, 2011 9:51 AM EDT

      I am what I am. -Popeye

      • 4 votes
      #34.1 - Tue Mar 29, 2011 1:34 PM EDT
      Reply

      "I'm here therfore I am."

        Reply#35 - Tue Mar 29, 2011 10:14 AM EDT

        Redundant!

          #35.1 - Tue Mar 29, 2011 10:30 AM EDT

          I believe the quote is, "I think, therefore I am." Cogito ergo sum, by philosopher Rene Descartes.

            #35.2 - Tue Mar 29, 2011 10:55 AM EDT

            I think, therefore I'm single.

            Would that be, Cognito ergo uno?

              #35.3 - Tue Mar 29, 2011 1:16 PM EDT

              Nemo nostrum per visum.

                #35.4 - Tue Mar 29, 2011 1:59 PM EDT
                Reply

                You broke it, you fix it.

                • 1 vote
                Reply#36 - Tue Mar 29, 2011 10:37 AM EDT

                You break it, you buy it.

                • 1 vote
                #36.1 - Tue Mar 29, 2011 10:14 PM EDT
                Reply

                "For this I had deprived myself of rest and health. I had desired it with an ardour that far exceeded moderation; but now that I had finished, the beauty of the dream vanished, and breathless horror and disgust filled my heart." I find this quote quite fitting

                • 2 votes
                Reply#37 - Tue Mar 29, 2011 10:42 AM EDT

                or "'Seek happiness in tranquility and avoid ambition, even if it be only the apparently innocent one of distinguishing yourself in science and discoveries.'"

                  #37.1 - Tue Mar 29, 2011 10:45 AM EDT
                  Reply

                  "What does not kill me makes me stronger." ~ Friedrick Nietzsche

                    Reply#38 - Tue Mar 29, 2011 10:44 AM EDT

                    "All kind of knowledge, eventually becomes self knowledge."

                    "Use only that which works, and take it from any place you can find it."

                    Bruce Lee

                      #38.1 - Tue Mar 29, 2011 2:41 PM EDT
                      Reply

                      Do or do not, there is no "try." - Yoda

                      • 3 votes
                      Reply#39 - Tue Mar 29, 2011 10:50 AM EDT

                      THIS is the winner. Stop the contest. this is the one.

                      • 2 votes
                      #39.1 - Tue Mar 29, 2011 2:00 PM EDT

                      You must unlearn what you have learned. ~ Yoda

                        #39.2 - Tue Mar 29, 2011 10:15 PM EDT
                        Reply

                        I always read viewpoints that suggest the bible is an interpretive piece.  However, in the case of the new testament, impossible fairy tales are corroborated by several witnesses.  And the clergy expects us to take the book as the complete truth.  I watched a preacher explain that there is no way dinosaurs ever existed because the world is only 6000 years old.  I have read the bible.  It is a great story with plenty of good moral value, but I will never believe that I can live the clean, honest life that I do, but still will be eternally damned because I did not pay homage to the right deity.

                        • 2 votes
                        Reply#40 - Tue Mar 29, 2011 10:54 AM EDT

                        "Religion delivered us from savagery, and sadly, will thrust us back"

                        -Some Guy

                          Reply#41 - Tue Mar 29, 2011 10:58 AM EDT

                          "I like your Christ, I do not like your Christians. Your Christians are so unlike your Christ." -- Mahatma Gandhi

                          • 2 votes
                          #41.1 - Tue Mar 29, 2011 2:35 PM EDT

                          "Trust me, I'm a limo driver!" ~ Dumb and Dumber

                            #41.2 - Tue Mar 29, 2011 10:38 PM EDT
                            Reply

                            I believe the new quote should be: "Oops, my bad."

                            • 1 vote
                            Reply#42 - Tue Mar 29, 2011 11:33 AM EDT

                            Ancora Impara --Michelangelo (trans: I am still learning)

                              Reply#43 - Tue Mar 29, 2011 11:54 AM EDT

                              "Where's the beef"

                                Reply#44 - Tue Mar 29, 2011 12:08 PM EDT

                                I've fallen and I can't get up.

                                  #44.1 - Tue Mar 29, 2011 2:01 PM EDT

                                  clap on

                                  clap off

                                  clap on, clap off

                                  the clapper!

                                    #44.2 - Tue Mar 29, 2011 10:35 PM EDT
                                    Reply

                                    Ooopps - did I do that? - Steve Eurkel

                                      Reply#45 - Tue Mar 29, 2011 12:33 PM EDT

                                      man plans-God laughs

                                      • 1 vote
                                      Reply#46 - Tue Mar 29, 2011 12:46 PM EDT

                                      DON'T PANIC!

                                      • 2 votes
                                      Reply#47 - Tue Mar 29, 2011 1:19 PM EDT

                                      42!

                                      my comment must be longer, so I've added this worthless sentence.

                                      • 3 votes
                                      #47.1 - Tue Mar 29, 2011 2:02 PM EDT

                                      There is a theory which states that if ever anyone discovers exactly what the Universe is for and why it is here, it will instantly disappear and be replaced by something even more bizarre and inexplicable.

                                      There is a second theory which states that this has already happened.

                                      • 4 votes
                                      #47.2 - Tue Mar 29, 2011 2:38 PM EDT
                                      Reply

                                      "When we tug on a single thing in nature, we find it attached to everything else."

                                      -John Muir

                                      • 3 votes
                                      Reply#48 - Tue Mar 29, 2011 1:24 PM EDT

                                      a bubble in a brook...a flash of lighting in a summer storm,

                                      a phantom and a dream...such is life.

                                      my favorite old Buddist saying...

                                        Reply#49 - Tue Mar 29, 2011 1:50 PM EDT

                                         Many people say they do not believe the Genesis account because they say that it was impossible that the earth was created in 7, 24 hour days! In fact, however, the word "day" as used in Genesis is translated from the Hebrew word "yohm", which can mean different time lengths. In some cultures the phrase, "In my father's day", is used,  implying more of a span of time than a 24 hour day.  The Bible uses the term, "in the day of harvest" which means during the harvest time which involves months, Genesis 30:14 and Proverbs 25:13. So, when the Bible uses the word "yohm", for the days of creation, it is speaking of a considerable amount of time for each day, milleniums even. Even in the beginning of Genesis, it speaks of the earth as already existing, before changes to nurture life began to happen at God's hand...Genesis 1:2. 

                                        Regarding the order of appearance of creation, many scientists say that the Bible is accurate when it discusses what was created first, second, third, and so on.  The Bible does not say how these things were created, but it does say that God is the one who did it.  The Bible is not a science book, but, whenever it touches on matters of science it is accurate.

                                        • 1 vote
                                        Reply#50 - Tue Mar 29, 2011 1:51 PM EDT

                                        "The Bible is not a science book, but, whenever it touches on matters of science it is accurate."

                                        Except in times when one needs to speculate about the meaning of each word used and the context in which it's used... A day is a day, if it was supposed to mean months or eons then the newer translations should say what is meant.

                                        You and I may believe the Earth was created over a long period of time, but many adherents to the Bible do in fact believe the Earth was created in (6) 24 hour days (lest we forget that God rested on the last day), 6000 years ago.

                                        • 1 vote
                                        #50.1 - Tue Mar 29, 2011 2:09 PM EDT

                                        Which scientists, have you read Genisis? because the order of creation stated cannot happen,

                                        Genesis 1:3–2:4

                                        The creation week consists of eight divine commands executed over six days, followed by a seventh day of rest.

                                        • First day: God (Elohim) creates light ("Let there be light!")[Gen 1:3]—the first divine command. The light is divided from the darkness, and "day" and "night" are named. (see fourth day how can you have light without the Sun? Seems God comes back to this on the fourth day, maybe it was his holiness that the light came from)
                                        • Second day: God creates a firmament ("Let a firmament be...!")[Gen 1:6–7]—the second command—to divide the waters above from the waters below. The firmament is named "skies".
                                        • Third day: God commands the waters below to be gathered together in one place, and dry land to appear (the third command).[Gen 1:9–10] "earth" and "sea" are named. God commands the earth to bring forth grass, plants, and fruit-bearing trees (the fourth command).
                                        • Fourth day: God creates lights in the firmament (the fifth command)[Gen 1:14–15] to separate light from darkness and to mark days, seasons and years. Two great lights are made (most likely the Sun and Moon, but not named), and the stars.
                                        • Fifth day: God commands the sea to "teem with living creatures", and birds to fly across the heavens (sixth command)[Gen 1:20–21] He creates birds and sea creatures, and commands them to be fruitful and multiply.
                                        • Sixth day: God commands the land to bring forth living creatures (seventh command);[Gen 1:24–25] He makes wild beasts, livestock and reptiles. He then creates humanity in His "image" and "likeness" (eighth command).[Gen 1:26–28] They are told to "be fruitful, and multiply, and fill the earth, and subdue it." The totality of creation is described by God as "very good."
                                        • Seventh day: God, having completed the heavens and the earth, rests from His work, and blesses and sanctifies the seventh day.

                                        What is funny is that Genesis is very generic, it says what God did, not exactly how he made it, as in the process involved in its creation (example you know that a car is made from parts and assembled but do you know the processes involved in making all those parts and how they interact to make it into its final usable product).

                                        Also one question that flies over peoples heads is this:

                                        What is a day to God, we measure time as a 24 hour period because it takes the earth 24 hours to do one full rotation. So what is a day to God who doesnt live on a planet? Who is the Alpha and Omega and has always been and always will be?

                                        I find it mind boggling that people measure the days God used to create things as 24 hours, what about before the earth was made how long was that day? If God does exist then evolution and the big bang would fit very nicely as it is basically the same process but over billions of years. Would a day to God be a billion years? 4 billion?

                                        Its all about Common sense, most things in the bible are metephors and cannot be take in a literal sense because when you place the laws of physics and how things work in the real world and add basic Common sense it all breaks down into a good story with SOME good messages (and that applies mainly to the new testament)

                                        I have asked pastors for explanations such as to Noah and how he feed all those animals, reptiles, birds, anphibians, insects (all the species on the planet and two of each) for 40 days and nights, the carnavores, the herbavors)? I mean really how big of a boat, there is no way he could provide for all the needs, what about waste?

                                        You know what I was told? That God provided for them, sorry but I dont remember the bible saying that. How can a person conjecture that but then rip people for doing the same thing about other passages.

                                        Its more likely that there was a local flood and he put all his own animals in the ark. Common sense questions can get no logical answers.

                                        • 2 votes
                                        #50.2 - Tue Mar 29, 2011 2:44 PM EDT

                                        Indeed PirateC, would it not have been beneficial to have the "God provided for them" part included in the book? It seems to me that the flood story, more than most oral traditions, has lost much of the message over time. We know there have been massive flood events from geologic evidence, and it's understandable that Noah's story has gotten so much attention. We humans do not want to be wiped off the planet. And who among us doesn't absolutely hate being generalized and grouped in with the rest of the garbage? Anyways, in the dimensions provided in the bible there is absolutely NO WAY Noah, or anyone for that matter, could have gotten two of each animal on the planet into that small of a space (even if there was half as much genetic diversity as there is today). And that's only the animals, that doesn't account for food or water or space for waste or shovels to remove the waste or living space for the people. The arc just isn't big enough. For the whole thing to make any sense (and I'm going WAY out on a limb here) the arc would have had to have been similar to Doctor Who's phone booth.

                                          #50.3 - Tue Mar 29, 2011 3:08 PM EDT

                                          And, one of those things I've always wondered, If the Sun and Moon were made the fourth day, what was the day measurement before that?

                                          As for the ark, maybe Noah was part "giant" and therefore had bigger limbs for measurement? But it still doesn't explain why the lions and tigers and crocodiles didn't eat everything else.

                                            #50.4 - Tue Mar 29, 2011 7:48 PM EDT

                                            • 1 vote
                                            #50.5 - Wed Mar 30, 2011 5:18 AM EDT

                                              #50.6 - Wed Mar 30, 2011 2:16 PM EDT

                                                #50.7 - Wed Mar 30, 2011 2:18 PM EDT

                                                  #50.8 - Wed Mar 30, 2011 2:23 PM EDT
                                                  Reply

                                                  so would your quote be 'sorry God ...didn't mean to peek'....

                                                    Reply#51 - Tue Mar 29, 2011 2:03 PM EDT

                                                    Shazam!

                                                      Reply#52 - Tue Mar 29, 2011 2:26 PM EDT

                                                      "Hate, war, poverty and injustice infect our world; but I did this because I could. It kept me from having to try to solve some of the world's actual problems. Venter"

                                                      • 1 vote
                                                      Reply#53 - Tue Mar 29, 2011 2:52 PM EDT

                                                      I like just the first part ""Hate, war, poverty and injustice infect our world; but I did this because I could." it could be applied to so many places

                                                        #53.1 - Tue Mar 29, 2011 2:58 PM EDT
                                                        Reply

                                                        Free nations are peaceful nations. Free nations don't attack each other. Free nations don't develop weapons of mass destruction. - George W. Bush

                                                        (he must have forgotten that America does indeed develop weapons of mass destruction. Either that or we are not free)

                                                          Reply#54 - Tue Mar 29, 2011 2:53 PM EDT

                                                          Freedom is the path of all nations if they want to survive into the future, with the way we are all connected it is getting to where it is impossible for people to not hear, see messages of freedom, it is easier for people to be connected to organize uprisings, just look at how facebook and other social networking sites have been used to do this.

                                                          This is an amazing time, history is being made. Leaders had best wake up because eventually they will have to answer to their peoples cries for freedom.

                                                          The world is changing, hopefully for the better. As long as people are not afraid to stand up for liberty then soon the entire world culture will be on a path to change for the betterment of humanity.

                                                          • 1 vote
                                                          #54.1 - Tue Mar 29, 2011 5:21 PM EDT

                                                          Excellent comment Pirate C. Very eloquent and poignant. I hope you are right and the world is changing for the better. Long live liberty!

                                                            #54.2 - Tue Mar 29, 2011 6:28 PM EDT

                                                              #54.3 - Wed Mar 30, 2011 2:54 PM EDT
                                                              Reply

                                                              My quote would be "Never trust a dog to watch your food." - Unknown

                                                              • 1 vote
                                                              Reply#55 - Tue Mar 29, 2011 3:22 PM EDT

                                                              Especially my dog because he is a Beagle and he has an addiction problem it is called food. He loves food so muhc that he would eat himself into a coma. Which is why I monitor his food intake. I am also immune to his OMG I am starving Puppy Dog stare.

                                                                #55.1 - Wed Mar 30, 2011 10:53 AM EDT
                                                                Reply
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