The tale of the Elvis-mouse hybrid: Why can't you be true?

Koby Barhad / RCA

Koby Barhad's concept for an installation called "All That I Am" suggests creating genetically engineered mice that reflect some of the traits associated with Elvis Presley. It's important to note, however, that no mice have yet been Elvisized.

A British artist’s plan to create a mouse with Elvis Presley’s DNA has set websites buzzing over the past week, but right now it’s nothing more than an art-school concept. And it's not clear whether the concept will ever go any further, due to ethical and legal concerns about blending human and animal DNA.

"The purpose of the work was to raise those almost frightening issues," artist Koby Barhad told me. Mission accomplished, Koby.


Actually, celebrity DNA is quite the commodity. A few years ago, a venture called MyDNAFragrance marketed several perfumes that supposedly reflected the DNA coding of Elvis as well as Michael Jackson and other dead celebs. (Sorry, those celebrity-themed fragrances, including "Blue Suede," are no longer available.) The DNA for that project came from University Archives' collection of historical hair. The Elvis hair that Barhad used came from another source: an eBay vendor who was selling strands for $22. (He says he also bought strands of hair attributed to Princess Diana and President John F. Kennedy.)

Barhad, a 35-year-old MFA student at London's Royal College of Art, said he didn't actually submit the Elvis strands for DNA sequencing. Instead, he conducted a practice run with the aid of a couple of researchers from Imperial College. The scientists analyzed DNA extracted from their own strands of hair, as well as from cheek swabs, to confirm that it would be possible to get some sort of genetic reading from the hair alone.

Barhad was particularly interested in seeing whether the DNA tests could identify a variant of the human ACTN3 gene that has been associated with athletic performance. "We proved that those particular scientists didn't have that gene," he told me. Theoretically, then, the DNA tests might be able to identify the genetic signatures of particular traits in Presley's DNA — although realistically, there's some question about how much the DNA might have degraded over the decades.

The next step in the concept would be to breed mice that reflected that genetic signature. Theoretically, you could insert a string of code from the Elvis genome into the desired mouse gene, through a procedure similar to that used to create lab animals with specific mutations. Barhad said another option would be to identify a genetic twist in the mouse genome that parallels the twist in the Elvis genome. For example, if Presley had a particular mutation of the ACTN3 gene, mice could be bred with a similar mutation.

Koby Barhad / RCA

Koby Barhad's concept envisions a stacked series of mouse cages that reflect different aspects of Elvis Presley's life.

The final step in Barhad's art project, titled "All That I Am," would put the Elvis-themed mice in a variety of postmodernistic cages that reflect phases of the rock star's life: One cage might have a funhouse mirror to enlarge the mouse's image, just as Presley's ego was enlarged by fame's mirror. Another would put the mouse on a treadmill, calling to mind how "Elvis worked himself to death" in his final years.

It's worth emphasizing that the Elvis mice do not exist, despite what some websites initially reported.

"I guess the project created a space to imagine a scenario we are all afraid of and want to experience at the same time," Farhad said in an email, "and that was the reason all the news [sites] published it as if I produced this specific mouse, instead of just suggesting it. The funny, or actually scary, thing is that a place in the U.S. ... already contacted me to buy the specific mice. So I think it kind of proves that it is much more real than I even imagined it would be. I'm still writing emails to everyone saying I didn't actually go as far as producing the clones."

In today's follow-up Skype voice call, Barhad said he had no intention of creating an Elvis mouse. "The thing I'm thinking of doing is having my own mouse" that would reflect his own genetic code, he said.

However, Barhad said he'd have to do some more research before going forward with that part of the art.

"Humanized" versions of genes, such as the FOXP2 gene that's associated with speech, have been inserted in mice for research purposes for years. But it's one thing to do that sort of thing under the stringent guidelines that govern genetic studies, and quite another to do it for an art exhibit — even if it's an exhibit designed to call attention to the controversy over transgenic DNA.

"I'm actually going over the law on that," Barhad told me.

Would it be wise for him do it? Or would Elvis observe that when it comes to splicing celebrity DNA, "only fools rush in"?

More about Elvis ... and DNA:


Tip o' the Log to Wired UK's Ian Steadman.

Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's Facebook page, following @b0yle on Twitter and adding the Cosmic Log page to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out "The Case for Pluto," my book about the dwarf planet and the search for new worlds.

Discuss this post

the crazy lady witch was right they are putting human brains in a mouse...hahahaha

  • 1 vote
Reply#1 - Thu Jul 19, 2012 6:26 PM EDT

This story hits a little close to home huh...Mr. Payne

For every thing that can be imagined, someone some where is trying to make it reality...

In a few Generations from now, Genetically Engineered Plants and Animals (food supply) and genetically altered Humans, will be the rule, not the exception or the taboo

  • 3 votes
#1.1 - Thu Jul 19, 2012 11:47 PM EDT
Reply

Let the poor mouse alone. Who knows, perhaps he wanted to look like Michael Jackson. To make him look like the King would be a crime.

LET THE MOUSE ALONE!

    Reply#2 - Thu Jul 19, 2012 6:41 PM EDT

    Blending human and animal DNA opens up far too many ethical questions. While doing it with mice would not yield any real problems, doing this with higher primates could cause some serious questions to come up as to when the hybrid crosses the line into being a human, and therefor acquiring all the rights of a human.

    • 1 vote
    #2.1 - Thu Jul 19, 2012 11:13 PM EDT
    Reply

    Ban the FrankenElvisMouse while it's not too late!!!

      Reply#3 - Thu Jul 19, 2012 9:23 PM EDT

      If only it was real :(

        Reply#4 - Thu Jul 19, 2012 10:07 PM EDT

        koby fish is brain food , go eat some

        • 1 vote
        Reply#5 - Thu Jul 19, 2012 10:13 PM EDT

        DAMN!

        All this time I could have been selling pubic hairs on e-bay!

        • 1 vote
        Reply#6 - Thu Jul 19, 2012 10:40 PM EDT

        OMG! This is creepy...it's not bad enough that we have messed up dogs...labradoodles, cockapoos, etc. It's a miracle that God hasn't smitten us for screwing with His dogs. HA! HA!

        Although, I guess if someone was a "weasel" his/her genes could be mixed with a weasel, and have an animal more representative of their personality trait. Just don't think this is wise idea...if you think something WON'T go wrong, it WILL.

          Reply#7 - Thu Jul 19, 2012 10:41 PM EDT

          Who would want a mouse the size of Elvis .... ??

          I'm glad it's just art for now ....

          Thanks Alan ....

          • 1 vote
          Reply#8 - Thu Jul 19, 2012 11:31 PM EDT

          of this mouse I would have to ask, pre-vegas or post-vegas?

          • 1 vote
          Reply#9 - Fri Jul 20, 2012 12:05 AM EDT

          "What are we going to do tonight Brain?"

          "Same thing we do every night Pinky, eat peanut butter and fried banana sandwiches and try to take over the world!"

          • 3 votes
          Reply#10 - Fri Jul 20, 2012 10:32 AM EDT

          ?

          • 1 vote
          Reply#11 - Fri Jul 20, 2012 10:43 AM EDT

          Don't be Cruel, Baby, Don't be Cruel.

          Yer Pal Always,
          Thee

          • 1 vote
          Reply#12 - Fri Jul 20, 2012 1:09 PM EDT

          This art student wants to create several transgenic mouse lines? I think he is underestimating the cost and difficulty a tad bit. Never mind that simply making a mouse with random DNA from a human might not look any different from the wild-type mouse (thus rendering his art quite lame). I don't know if he is imagining a fat mouse with a pompadour or what, but it probably won't turn out the way he wants it. That's simply not how it works.

          Then of course there are the legal hurdles to fund this work. At least in America if you want to do these kinds of projects there needs to be serious review of the necessity for creating the transgenic line as well as the way in which these animals will be housed and bred. This project has no scientific purpose, thus I doubt it would ever get the funding required to carry it through. And I doubt this artist wants to shell out the dough himself. Further, any scientist who lends their expertise to this project would be forever labeled as a risk for all future animal projects - not the kind of thing one wants to do to their career. This is not the kind of thing that can be done in a garage either.

          This is therefore only a story about some artists idea, which is far from happening. Thus, lame.

          • 1 vote
          Reply#13 - Fri Jul 20, 2012 1:24 PM EDT

          This sounds like something which Disney World would totally go for. Gee, maybe that is the (secret) method to the madness. - RC

            Reply#14 - Sat Jul 21, 2012 5:03 PM EDT

            "Thank you, thank you, thank you every munch.

              Reply#15 - Sun Jul 22, 2012 11:44 PM EDT
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