Where did your ancestors come from? What's your genetic lineage? The Genographic Project is answering these questions and more. And in doing so, it is solving the riddle of who we are and how we're all related.
Seven years ago, National Geographic launched a project aimed at using genetic analysis to map tens of thousands of years of human migration — and now a new phase of the Genographic Project promises to bring even more precision to that map.
"With the number of markers we've added, we've gotten much closer to the present," the project's director, population geneticist Spencer Wells, told me this week.
The key to tracing genetic connections lies in chemical markers — specific strings of DNA coding that are passed down from one generation to the next. When the Genographic Project was founded in 2005, scientists tracked 12 markers on the Y chromosome of male participants, or about 150 markers in the mitochondrial DNA of men or women. The Y-chromosome DNA could track only the paternal lineage, and the mitochondrial DNA readings could track only the maternal line.
Genographic 2.0 has kicked it up a notch: A testing tool known as the "GenoChip" has been custom-designed for this second phase of the project. Now the project looks at 12,000 DNA markers on the Y-chromosome, 3,300 mitochondrial DNA markers, and 130,000 other markers from each participants' genome. Such a huge database could theoretically correlate your genetic heritage with your ancestors' regional ramblings, even if they're not on the direct paternal or maternal line, Wells said.
The data analysis even correlates your genetic information with that of the long-extinct Neanderthal and Denisovan species of near-humans. Researchers have found that non-Africans can trace up to 4 percent of their genetic makeup back to the Neanderthals, and that modern-day Papuans owe about 6 percent of their genetic heritage to the mysterious Denisovans. So how much of a Neanderthal are you? Genographic 2.0 could let you know.
"Your own DNA tells an incredible story of how your ancestors embarked on an epic journey that populated the earth," Wells explains in a video about Geno 2.0.
The testing routine is relatively simple, if a bit pricey: First, you purchase a mail-order sample kit for $199.95. When you receive the kit, you run a cotton swab around the inside of your cheek to pick up some of your cells, then seal up the swabs and send them back to the lab. A few weeks later, you can review your results on a password-protected Web site.
Geno 2.0 isn't the only gene-sampling program that's out there: Several companies offer Y-chromosome or mitochondrial-DNA testing from genealogical purposes. In fact, Geno 2.0 is partnering with one of those companies, Family Tree DNA, to provide the cheek-swab testing service. Other companies such as 23andMe and Complete Genomics can sample a wider swath of your genome, or even your entire genome. (23andMe also gives you percentages for Neanderthal DNA, by the way.)
Wells' project is different in that genealogy is not Geno 2.0's primary purpose, and the genetic markers are not linked to medically relevant traits. So you can't use the results to calculate your risk of falling prey to disease. But you can get a sense of where your long-ago ancestors came from, in what percentages. For example, oceanographer Robert Ballard discovered that his mostly Dutch-British genome is also about 2 percent Oceanian, connecting him with the seafarers who plied Pacific waters tens of thousands of years ago.

National Geographic
Population geneticist Spencer Wells, director of National Geographic's Genographic Project, says the latest phase of the project should provide new opportunities for citizen scientists as well as professional researchers.
Even though Geno 2.0 is not a family-tree project per se, it's still possible to compare your genetic profile with others via the project's community forum. "We display people who have genetic profiles similar to yours as 'dots' in your circle," Wells said. You can "ping" those dots to ask other Genographic participants for more information about their heritage.
"This allows them to remain fairly anonymous, and yet share their story," Wells said.
Wells and his colleagues are also awarding grants, to fund research using Geno 2.0's anonymized genetic database as well as to support initiatives for indigenous and traditional communities around the world. The Genographic Project has already provided 62 Legacy Fund grants, worth $1.7 million, for initiatives in locales ranging from Guatemala to Nepal. There's also an education program called GenoThreads, which aims to connect classrooms around the world via email and videoconferencing. The first GenoThreads project is connecting high-school students in Switzerland and Singapore.
More than half a million people participated in the first phase of the Genographic Project, which distributed the testing kits for $99. Geno 2.0 is twice the price — which has sparked a few critical comments from Geno 1.0 participants.
"We bought this for our son and the results were vague ... like we started in Africa. Yeah, everybody did," one commenter wrote in a posting on National Geographic's YouTube page. "Then some of our line went to East Asia and some went West. Then the info stops. Oh, unless we want to buy Phase Two for $199. This was very disappointing."
I've had my DNA tested for several projects in the past, including Family Tree DNA as well as Geno 1.0, and although the tests have helped me exclude some suspects in the family search, I haven't yet hit the genealogical jackpot. Genetic testing has identified unexpected connections between other Boyle kin, however, so I know the technology works. Maybe I'll give Geno 2.0 a try and file a follow-up report. In the meantime, feel free to let me know how your own genetic quest is turning out.
More from the Genographic Project:
- Ancient Phoenicians' genetic heritage lives on
- Phew! Humans may have faced extinction
- Human migration traced through genes
Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's Facebook page, following @b0yle on Twitter and adding the Cosmic Log page to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out "The Case for Pluto," my book about the controversial dwarf planet and the search for new worlds.


Uhh maybe were related Alan... distantly.. (snicker)... can I use you as a reference.. cousin?... lol.
Joking aside... I would be interested in my DNA lineage.. if nothing else that would be interesting... the 200.00 dollar price tag (for me) is daunting though. I can see the immediate science value if more people around the globe would participate. There was a TV series (documentary) called Finding Eve.. .. Does any one know if any of this research came from that?
The "Eve" thing was quite awhile ago and only a simplistic first step. All it did was look for the common ancestor of all present-day mitochondrial genomes. It got an age of about 200,000 years i think but it wasn't very precise. The current effort is much more sophisticated and concentrates in more recent history.
Here is a link to that show I'm refering to:
http://topdocumentaryfilms.com/real-eve/
every few months there is another ad (read news story) for getting your map. I fell for it a while back and the results were less than stellar, your not going to get anything that you think you are.
It's sad that folks like Sauve speak so negatively, but haven't connected up with any of the online communities that could help you get so much more out of your test results. You do have to be willing to learn a little more, not just sit back and expect all the information you were thinking you would get to be instantly available. But the Geno 2.0 is really a fantastic state of the art test, certainly worth $199, and already, though it just came out, something like 10,000 people have ordered it. There will definitely be lots of people from around the globe you'll be able to compare your results with. After you get your results from Genographic, you really need to connect up your profile with Family Tree DNA, where you can search for matching people and contact them. If you haven't yet done that from your Geno 1.0 results, Sauve, you ought to at least make that much effort, before you talk about "falling for it." There are a heck of a lot of us who are very happy with what we're finding. The more time and energy you put into it, the more you get out. I don't work for FTDNA, I am a volunteer project admin.
Bonnie, i haven't figured out how to do that, link to the Family Tree so I can compare results with others. Can you please let me know what else I have to do beside trying to log on. Will I have to buy something else?
Hi Bonnie I bought two of the older kits a Paternal Y and a Maternal Mitochondrial in 2008 I forgot about them until recently upon finding them in my cellar. The kits are both unopened and were stored in a cool dry place. I'm curious if you'd know if these were still ok to use and send in. I sent and e-mail to the GenoGraphic Project but recieved a generic e-mail back. I haven't been able to find anything in the FAQ's or related articles about persons like myself who have older unused kits. Any opinion you have would be considered just that but deeply appreciated. Thanks, David in Seattle
Hi Bonnie, thank you for your informative post. I have a question you might help me with I have two unopened kits one Paternal Y and one Maternal Mitrochodrial. They are unopened and have been stored in a cool dry place since 2008. Do you believe they are still useable. I tried getting a response via e-mail from the GenoGraphic Project but due to volume it was generic and only referred me to a link to their FAQ's which I've searched and looked at other items on the site unable to find out about older kit's any help would be deeply appreciated. Again, Thanks David Seattle
Bonnie Cicada here. I apologize for the duplication. I had to register and didn't know my original note to you was going to post. Again Thanks
Listen Bonnie you have no idea what I have done or have not done so stop flapping your gums like you know something no one else does. By the looks of it your a shill working for the company, lol.
I ordered the kit and got my results-it's really awesome. They have a great website where you can check your results. BUT-if your a female, they can only test your maternal line, male-paternal line.
I think it was worth it. I am a blue eyed blonde and my results were 47% Northern European-British/Denmark, 37% Mediterranean (Italy/Greek/Egypt & 17% Southeast Asia-Iran. Also, my results for Neanderthal & Denisovans .08 % each ... who knows about that part-but who really cares about that part, anyway. The percentages are not on a 100% system, so they don't add up to 100.
Julie, I too have been tested but I can't get any Y-DNA because I don't have any brothers or male cousins on paternal side to test. I sure wish there was a way to get the information about my father's side. I am also blonde haired and blue eyed and of German descent. My results tell me that I am Northern European but also mostly from the Siberian line, which is consistent with the Ukrainian blood I carry from my mother. A surprise for me was that there is indication from the Middle East. I do love the site though and spend lots of time on it eveyday. I am getting complaints from my husband.
I've been fascinated by this for awhile and finally sent in my samples....I am the oldest of 5 (female) and have two sisters and two brothers....when I get my results back, I may ask one of my brothers to send for a kit so we'll have a more complete picture. I think it's so interesting and can't wait to learn more.
Linda, I have no husband to complain about how much time I spend looking in to all this, but my cats give me hell!! :-)