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  • 7
    Dec
    2011
    5:03pm, EST

    3-D model of rat brain circuit created

    Getty Images file

    In this file photo, a worker holds a white rat in a lab. Scientists have developed a 3-D model of a rat brain research, they report in a new study.

    By John Roach, Contributing Writer, NBC News

    After six years and several million dollars, scientists have created a 3-D model of a rat brain circuit.

    The accomplishment is a first step toward creating a complete computer model of the brain that will allow a deeper understanding of how our noggins work — and what causes them to malfunction, according to the scientists behind the feat.


    For a starting point, researchers at the Max Planck Florida Institute are focused on how the rat brain processes information gathered by a single whisker.

    They did so because studies in their lab and elsewhere have shown that a single whisker is able to detect, in complete darkness, whether a gap is safe to jump over and, if so, trigger the order to jump. 

    What's more, there's a specific region of the brain "that is dedicated to processing information from a dedicated whisker," Marcel Oberlaender, a researcher at the institute and the first author of a paper explaining the research in the journal Cerebral Cortex, told me today.

    That region is called the cortical column, a vertically-organized series of connected neurons that form a brain circuit and an elementary building block of the cortex. 

    The cortex is the part of the brain responsible for many of the higher functions, such as memory and consciousness.

    To build the model, the researchers studied the cortical column in awake and anesthetized rats as well as brain slices and then used computer software and other tools to reconstruct it.

    "The model we built is really based on a complete reconstruction of these nerve cells," Oberlaender said. "So how the model looks in the end resembles how it would look in the real animal."

    It is composed of 16,000 neurons, each of which can be divided into one of nine different cell types that has characteristic functional, structural and connectivity properties, he added.

    The model can now be used to run computer simulations that show, in realistic detail, how signals flow within the brain. So, they can begin to understand, for example, what neurons fire as the rat detects the gap and decides whether or not to jump.

    Until now, researchers have only been able to see how a single neuron or a small group of neurons interact during such a process. "We can now, in simulation experiments, mimic what is really going on in these circuits," Oberlaender said.

    Going forward, the researchers should be able to use the methodology developed to build this model to add more parts to it, thus incorporating other brain functions such as the motor system that sends a signal down the spinal cord and makes the limbs move so that rat can jump over the gap.

    More on brain science and technology:

    • 3-D brain model could revolutionize neurology
    • Test-tube brain aces 'plop' quiz
    • 'Brain in a dish' may lead to stroke recovery
    • Cat brain inspires computer of the future
    • IBM unveils brain-like chip
    • Breakthrough chip mimics human brain function

    John Roach is a contributing writer for msnbc.com. To learn more about him, check out his website. For more of our Future of Technology series, watch the featured video below.

    Kids' play has moved to tablets and PCs. In this new age, toy makers and researchers alike are sorting out the benefits — and detriments — of playful educational interaction in virtual space.

     

    19 comments

    This is a really important milestone. Cortical columns aren't just for whiskers -- they are a fundamental processing unit throughout the entire neocortex. When we understand them here, we will be a long way towards understanding how the cortex works in general.

    Show more
    Explore related topics: science, brain, innovation, model, featured, 3-d

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John Roach, Contributing Writer, NBC News

John Roach is a contributing writer for NBC News. From climate change and mass extinctions to human evolution and deep space, his writing explores life on Earth and its place in the universe. He was a staff writer at the Environmental News Network for several years and has contributed to National Geographic News for more than a decade.

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